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MacuCLEAR Inc.
Medical Devices & Tech
2300 McDermott Road Suite 200-147
Plano, TX 75025 USA
phone:(214) 577-5999
fax:
Symbol Private
Founded 2006
Employees
www.macuclear.com
Research Sector Medical Devices & Tech
Summary Description
is developing a novel treatment for age related macular degeneration
Management
Philip Ralston, President and Co-Founder; Ron Buren, Principal
Keywords
vascular, macular degeneration, retinopathy, diabetic retinopathy, ischemic retinopathy, eye, eyes

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Updated: Jun. 06, 2011

Description
MacuCLEAR Inc. is a specialty clinical-stage pharmaceutical company focused on developing and commercializing novel solutions for vascular disorders of the eye. It's first target is Age Related Macular Degeneration, (AMD), the leading cause of blindness for people over 50 years of age, affecting 30 million people worldwide, representing a $5Billion market, for which there is currently no approved treatment for 90% who have this terrible disease. It is at the Phase II human clinical trials stage.
Products / Services
The company currently has 4 patents around this technology. MacuCLEAR obtained, through an exclusive worldwide license from Texas A&M University, MC-1101 and numerous other compounds. Additional research continues in this area and MacuCLEAR intends to file additional patents in the near future.
Technology / Differentiation
MacuCLEAR's lead proprietary compound, MC1101, is being developed to treat the dry form of AMD. Challenging conventional wisdom, this novel compound is delivered preservative-free by a proprietary eye drop delivery system. Diabetic retinopathy and other retinal diseases will also be investigated with MacuCLEAR's portfolio of drug candidates. While novel in this ophthalmic application, the active ingredient of MC1101 has been previously approved by the FDA as an oral antihypertensive drug. Its safety and toxicity profile is well characterized. MC1101 has been granted 505 (b) 2 status and has formal Fast Track designation by the FDA. MacuCLEAR's Technology Objective is to prevent progression of Dry AMD to Wet AMD by: 1) restoring choroidal blood flow, 2) thus preventing the rupture of the Bruch's Membrane, the integrity of which is known to be the fundamental difference between the dry and wet forms of AMD; 3) treating aging effects of inflammation and oxidative stress. MacuCLEAR's successful completion of its Phase Ib/POC not only proved MC-1101 is safe and well tolerated by all study subjects, it further proved MC-1101 gets to the back of the eye, and when it gets there, significantly improves choroidal blood flow. Since impaired blood flow has been shown to contribute to the progression of dry AMD, the consensus is these study results suggest MC-1101 may be a useful therapeutic agent for the treatment of dry AMD and the potential multifunctional benefits of MC-1101 to subjects with dry AMD should be further explored.
Market / Customers
Age Related Macular Degeneration (AMD) is the leading cause of legal blindness in the world, with the early stage, or dry form affecting 90% of the millions who suffer from this pandemic problem of our aging population. The market is huge, representing billions of dollars, and as of now, no approved treatment is available.
Funding
MacuCLEAR will grow through strategic alliances, consistent with the industry trend of large pharmaceutical and biotech companies seeking novel drugs to fill their product pipelines and diminishing intellectual property portfolios. The company intends to out-license its portfolio of novel drug formulations for various ophthalmic diseases and will derive income from licensing fees, milestone payments and royalties. MacuCLEAR completed its Series A Preferred Stock sale, raising $3.8M, including $1.7M from the Texas Emerging Technology Fund. These funds were used to complete its Phase I Human Clinical Trial. MacuCLEAR is seeking $7M which will be used for its Phase II Human Clinical Study. Stock Purchase details are available through the "Contact Us" page.