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460, Totten Pond Road, Suite 650
Waltham, MA 02451 USA
phone:781.419.1400
fax:781.419.1420
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| Symbol |
private |
| Founded |
2005 |
| Employees |
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| www.syndax.com
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| Research Sector |
Biotech Specialty Pharma |
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| Summary Description |
| Developing and commercializing novel therapies for cancer patients. |
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| Management |
| Joanna Horobin, MD, President & Chief Executive Officer; Robert Goodenow, PhD, Chief Business Officer; Gloria Lee, M.D., Ph.D., Vice President of Clinical Development; Miranda M.C. Rees, Vice President, Product Development; Peter Ordentlich, PhD, Director, Scientific Affairs/Strategic Relations & Founder |
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| Keywords |
| lung cancer, tumor phenotype, hdac inhibitor, clinic, renal cell cancer |
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| Description |
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Syndax Pharmaceuticals, Inc., was founded in 2005 to extend and improve the lives of cancer patients by developing and commercializing novel therapies. Their vision is to modify the tumor phenotype, allowing for new therapeutic opportunities that restore or extend the benefit of targeted therapies. They aim to accomplish this by developing effective regimens that have broad commercial potential by optimizing features important to patients, physicians, and payers. The Company's lead product is entinostat (SNDX-275) (entinostat; formerly MS-275), an oral HDAC inhibitor that acts synergistically with targeted therapies. entinostat (SNDX-275) is selective for cancer-relevant HDAC isoforms 1, 2, and 3, and preclinical evidence suggests their inhibition can modify the tumor phenotype to restore sensitivity to targeted therapies. |
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| Technology / Differentiation |
| Histone deacetylase (HDAC) inhibitors are excellent candidates to test the therapeutic potential of tumor phenotype modification. Based on a robust preclinical platform and multiple Phase 2 clinical studies in breast, lung and lymphoma in over 400 patients, we believe that entinostat (SNDX-275) is a highly promising oral HDAC inhibitor |
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Biotech & Specialty Pharma
Healthcare Services
Medical Devices & Tech
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