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Abviva
402 E. Gutierrez Street
Santa Barbara, CA 93101 USA
phone:(800) 970-5870
fax:(800) 970-5874
Symbol ABVV
Exchange PK
Founded 0
Employees
www.abviva.com
Research Sector
Summary Description
Established to develop and commercialize diagnostic and therapeutic products.
Management
Ownership
Financials


* numbers in thousands
 

Keywords
develop, commercialize, diagnostic, therapeutic, products, breast cancer, growth, inhibitory, protein

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Updated: Mar. 21, 2011

Description
Abviva, Inc. was established to develop and commercialize diagnostic and therapeutic products from a novel breast cancer growth inhibitory protein. Research scientists at the prestigious University of Michigan Cancer Center discovered a secreted protein produced in normal breast epithelial cells that inhibits the growth of breast cancer. Abviva intends to build a fully-integrated diagnostic and therapeutic business that is sustained by future revenues from products and services the company develops; to commercialize the Mammastatin Serum Assay through our wholly owned subsidiary laboratory; and, to develop one or more breast cancer therapies through internal and external collaborative research with pharmaceutical, biotechnology and leading research institutions world wide.
Products / Services
Mammastatin and Breast Cancer Mammastatin was first described as a tissue-specific growth-inhibitory protein in the journal Science by the discovering cancer research scientists at the University of Michigan Cancer Center. Mammastatin was first isolated from normal human mammary cells grown in laboratory tissue culture. The protein was identified in tissue sections within the epithelial cells lining the lumen of the mammary duct. The protein is secreted into the blood stream and can be detected by a simple blood test in human serum. Breast cancer cell growth is inhibited in cell culture when mammastatin is applied. This inhibition is specific to breast cancer cell lines. Most women treated under Compassionate Use with an early therapeutic preparation of Mammastatin showed improvement with their breast cancer, including reduction of bone metastases and prolonged life. The Mammastatin Serum Assay The Mammastatin Serum Assay (MSA) measures a woman's risk of developing breast cancer. It is a simple blood test that detects and measures the amounts of Mammastatin in blood serum. The MSA has been studied as a means to provide early detection of women with breast cancer who have no symptoms and are undiagnosed, and to identify women who are at increased risk of developing breast cancer before cancer develops when conventional diagnostic tests are ineffective. In clinical studies conducted on 594 women, 98% of women in the studies who had no history of breast cancer had elevated or moderate levels of mammastatin in the blood serum as measured by the Mammastatin Serum Assay. Conversely, 74% of women in the same studies who had breast cancer or who had a family history of breast cancer had no detectable levels of Mammastatin or very low levels. A Test That Aids In Early Detection The MSA offers a biological measure of breast cancer risk assessment so that personal and physician attention may be focused on early detection of breast cancer. When detected early women can have up to a 98% probability of surving breast cancer. The MSA is developed to help women and their physicians identify breast cancer early and and to identify women who have an elevated risk of developing breast cancer.
Technology / Differentiation
Abviva?s research interests are directed toward innovating and developing breast cancer diagnostic and breast cancer therapeutic products that can benefit individuals throughout the world. Abviva intends to conduct basic, translational and clinical research with biotechnology, pharmaceutical and leading university and government institutions world wide through internal and external collaborative research. We intend that research conducted on mammastatin will advance the knowledge and understanding of the biological mechanisms underlying the mammastatin phenomenon as well as advance the scientific, medical, diagnostic and therapeutic understanding of mammastatin and breast cancer.