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GlySure
Medical Devices & Tech
Units 4-6 The Quadrant, Abingdon Science Park
Abingdon, Oxfordshire OX14 3YS United Kingdom
phone:+44 (0)1235 462 870
fax:
Symbol Private
Founded 2006
Employees 14
www.glysure.com
Research Sector Medical Devices & Tech
Summary Description
Intravascular glucose monitoring sensor for Tight Glycemic Control
Management
Christopher Jones, CEO; Barry Crane, CTO; John Bradshaw, CFO; Roger Pamment, VP of Product Marketing; Jan Walters, VP of Regulatory Affairs & Quality
Keywords
glucose monitoring, intravascular, optical fluorescence-based sensor,tight glycemic control,insulin therapy

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Updated: Feb. 22, 2012

Description
Glysure has developed an intravascular glucose-monitoring sensor to enable effective clinical implementation of Tight Glycemic Control (TGC) in hospital ICUs. In 2001, research demonstrated that tightly controlling glucose levels in the ICU can significantly decrease mortality rates. However, contemporary methods of glucose monitoring remain time-consuming and costly, which results in far less frequent monitoring than should occur. Glysure’s continuous intravascular glucose sensor seamlessly integrates into existing ICU vascular access, providing hospitals with a safe and easy means of implementing TGC without disrupting preexisting functions of intravascular lines. It requires minimal maintenance throughout a patient’s stay, thereby reducing both time and cost. This earlier-stage medical device company’s trials in human serum, plasma, and whole blood confirmed that the sensor can measure glucose levels across the entire human physiological range with an extremely high degree of accuracy; the fluorophore-receptor indicator of the sensor is patented under exclusive license to Glysure, which is currently conducting its first human-use ICU trials.
Products / Services
The GlySure System comprises two main parts, a monitor and a sterile disposable set (which includes a fibre-optic sensor and integrated calibration module).

The sensor interfaces with the patient's pre-existing intravascular line (arterial or venous) without disrupting the clinician's ability to monitor pressure, draw blood or administer medication through those lines.

The GlySure System allows fast, easy, non disruptive set-up which works with existing supplies and requires minimal maintenance throughout the length of patient stay.
Market / Customers
Infrequent glucose monitoring could be putting patient lives at risk. At present, clinicians do not have an easy, accurate and affordable technology to allow the frequent glucose monitoring required for Tight Glycemic Control (TGC) protocols.GlySure's new technology exceeds the requirements of clinicians while also significantly reducing time and cost.
Strategy
Since the NEJM paper, and over the past ten years, the practice of TGC and Intensive Insulin Therapy (IIT) has been widely adopted in hospitals worldwide.

However, most hospitals will admit that TGC/IIT causes them significant cost and resource problems and that maintaining a patient's glucose level within the target range is difficult using current clinical practice. Glucose monitoring is generally done manually by nursing staff, mainly using finger sticks and hand-held glucose meters. This practice is time consuming (up to 15 minutes per sample, including therapy adjustment) and greatly increases nurse workload.

A study conducted by Daleen Aragon on the impact of TGC implementation on nursing concluded: "Because up to 2 hours might be required for tight Glycemic control for a single patient in a 24-hour period, the costs in time and money are high."

As a result, glucose monitoring is currently performed at a frequency that is unacceptable and could be putting patient lives at risk. Infrequent sampling significantly reduces patient care benefits while increasing the risk of hypoglycaemia. To date, the single greatest barrier to adopting TGC/IIT is the absence of an appropriate technology on the market to meet the need for tight control, ease of use, and automated monitoring.