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45 Kulick Road
Fairfield, NJ 07004 USA
phone:973-575-2551
fax:973-227-0151
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Private |
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| www.physion.com
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| Research Sector |
Medical Devices & Tech |
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| Summary Description |
| Electromotive Drug Administration (EMDA) for Urological Drug Delivery |
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| Management |
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| Keywords |
| drug delivery, urology |
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| Description |
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Physion is an Italian company specializing in technology that facilitates cost-effective and efficient drug delivery. The company has patented the EMDA (Electromotive Drug Administration) system, which allows for the active electrochemical transport of soluble drugs into tissues via iontophoresis and electro-osmosis. EMDA is intended for various urological indications, including bladder cancer and Peyronie's disease. |
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| Products / Services |
The Miniphysionizer (R) 2.0 is a simple, small current generator recommended for andrological and musculoskeletal pathologies. It is powered by a single 9V battery and its output current is 2.0 mA. An internal microcontroller within the Miniphysionizer (R) 2.0 provides safety and automatic set-up of treatments. The generator has two output cables, which connects to the CT-DAS (R) cutaneous electrode (anode) and to the dispersive electrode (cathode). The CT-DAS (R) (a single-use, non-sterile and disposable electrode) contains the drug solution whose ionized molecules are to be transported by the electric current. Treatment with EMDA is painless and can be performed at home.
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| Technology / Differentiation |
| Iontophoresis refers to the active transport of ionized molecules in solution into tissues by application of an electric current, while electro-osmosis describes the active transport of non-ionized solutes in water along with ionized solutes. Physion's EMDA technology combines these processes to facilitate transport of almost any soluble drug to the tissues in intravesical solution, resulting in greater quantities of drugs being delivered to greater tissue depths than would be achievable by passive intravesical diffusion. The intensity of the electric current can be regulated by the physician, so the rate of drug administration is fully controllable. The CT-DAS (R) electrode is constructed of PVC and contains a skin adhesive. The drug solution is inserted within the electrode via syringe through a small hole in the upper section. This hole is located in the center of a conductive element, which contains a silver component enabling connection to the generator. The dispersive electrode is made of a stainless steel grid sandwiched between layers of non conductive absorbent cellulose-based foam. When placed upon a layer of ECG gel, it permits the application of current for twenty minutes of therapy with minimal to absent thermal damage to the skin of the thigh. |
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| Market / Customers |
Peyronie's disease, characterized by a hard lump (plaque) that develops on erectile tissue of the penis, currently affects 1.4 million men. Approximately 400,000 Americans currently live with bladder cancer and 60,000 new cases are diagnosed each year.
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| Status |
| Previous studies of Peyronie's patients have demonstrated a reduction in plaque volume, reduction of penile deviation, and elimination of pain in over 66% of patients from the administration of verapamil through EMDA. A January 2006 study of bladder cancer patients illustrated that the electromotively delivered mitomycin C, coupled with BCG treatments, prolonged disease-free intervals more than three-fold, lowered recurrence rates, and slowed disease progression. |
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Healthcare Services
Medical Devices & Tech
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