Medical Devices & Tech

ISTO Technologies

1155 Olivette Executive Parkway, Suite 200
St. Louis, MO 63132 USA
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Research Sector Medical Devices & Tech

Summary Description Cell-Based Technologies and Biomaterials for Orthopedics Treatment

Management Joseph Feder, Ph.D., Chairman of the Board; Mitchell Mitchell Seyedin, Ph.D., President and CEO; John Hart, Chief Operating Officer; Scott Gill, Chief Financial Officer; Penny White, RAC, Vice President, Regulatory Affairs & Quality Assurance; Gary Gage, P.E., Vice President, Program Management

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Keywords: orthopedics, cartilage and bone regeneration, regenerative technologies, spine and knee therapy, injectable cell therapy, disc nucleus repair, live cartilage implant, bone graft extender, spine fusion, bone growth, biologics, biomaterials, osteoarthritis


Updated: Nov. 29, 2016


ISTO Technologies, Inc. (, based in St. Louis, MO , is an orthobiologics company developing innovative cartilage and bone regeneration products for spinal therapy, sports medicine an......view more

Products / Services

The Company's leading cartilage product is RevaFlex, an off the shelf scaffold-free engineered cartilage tissue implanted onto focal knee cartilage defects using a biologic glue. With over 5 years fo......view more

Technology / Differentiation

Based on the fact that cartilage cells and tissue are immune-privileged, ISTO's platform technology for cartilage regeneration centers on the use of allogeneic cells that that are derived from juvenil...view more

Market / Customers

Cartilage regeneration is considered the "Holy Grail" of orthopaedics. Cartilage covers the surface of bone in all of the joints (i.e. knees, hips, shoulders, ankles and spine) and works as a shock ab......view more

Revenue / Funding

Since inception in 1997, ISTO has raised approximately $45 million to fund its' research and development efforts. The Company's major shareholders include Alafi Capital, LLC; Ascension Health Venture...view more


Leading platform technology for cartilage regeneration - ISTO is the only company with a cell-based platform technology for cartilage regeneration. Some of the key advantages for ISTO's cartilage tech...view more